Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Msx1  msh homeobox 1   (Synonyms: Hox7, Hox-7, Hox7.1, msh, muscle-segment homeobox)
Results	Reference
1*	J:92174 Aberg T, Wang XP, Kim JH, Yamashiro T, Bei M, Rice R, Ryoo HM, Thesleff I, Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol. 2004 Jun 1;270(1):76-93
1	J:88218 Alappat S, Zhang ZY, Chen YP, Msx homeobox gene family and craniofacial development. Cell Res. 2003 Dec;13(6):429-42
1	J:170583 Baek JA, Lan Y, Liu H, Maltby KM, Mishina Y, Jiang R, Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Dev Biol. 2011 Feb 15;350(2):520-31
1	J:314666 Balasubramanian R, Min X, Quinn PMJ, Giudice QL, Tao C, Polanco K, Makrides N, Peregrin J, Bouaziz M, Mao Y, Wang Q, da Costa BL, Buenaventura D, Wang F, Ma L, Tsang SH, Fabre PJ, Zhang X, Phase transition specified by a binary code patterns the vertebrate eye cup. Sci Adv. 2021 Nov 12;7(46):eabj9846
1	J:223863 Bhattaram P, Penzo-Mendez A, Kato K, Bandyopadhyay K, Gadi A, Taketo MM, Lefebvre V, SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis. J Cell Biol. 2014 Dec 8;207(5):657-71
1*	J:116770 Britanova O, Depew MJ, Schwark M, Thomas BL, Miletich I, Sharpe P, Tarabykin V, Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development. Am J Hum Genet. 2006 Oct;79(4):668-78
1	J:274818 Chen Y, Wang Z, Chen Y, Zhang Y, Conditional deletion of Bmp2 in cranial neural crest cells recapitulates Pierre Robin sequence in mice. Cell Tissue Res. 2019 May;376(2):199-210
1*	J:124124 Core N, Caubit X, Metchat A, Boned A, Djabali M, Fasano L, Tshz1 is required for axial skeleton, soft palate and middle ear development in mice. Dev Biol. 2007 Aug 15;308(2):407-20
1*	J:101319 Coudert AE, Pibouin L, Vi-Fane B, Thomas BL, Macdougall M, Choudhury A, Robert B, Sharpe PT, Berdal A, Lezot F, Expression and regulation of the Msx1 natural antisense transcript during development. Nucleic Acids Res. 2005;33(16):5208-18
1	J:309519 Dasgupta K, Cesario JM, Ha S, Asam K, Deacon LJ, Song AH, Kim J, Cobb J, Yoon JK, Jeong J, R-Spondin 3 Regulates Mammalian Dental and Craniofacial Development. J Dev Biol. 2021 Aug 12;9(3)
1	J:152420 Denaxa M, Sharpe PT, Pachnis V, The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition. Dev Biol. 2009 Sep 15;333(2):324-36
1	J:93954 Ding H, Wu X, Bostrom H, Kim I, Wong N, Tsoi B, O'Rourke M, Koh GY, Soriano P, Betsholtz C, Hart TC, Marazita ML, Field LL, Tam PP, Nagy A, A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat Genet. 2004 Oct;36(10):1111-6
1	J:30057 Dudley AT, Lyons KM, Robertson EJ, A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev. 1995 NOV 15;9(22):2795-2807
1*	J:86790 Gitler AD, Lu MM, Jiang YQ, Epstein JA, Gruber PJ, Molecular markers of cardiac endocardial cushion development. Dev Dyn. 2003 Dec;228(4):643-50
1	J:99936 Givens ML, Rave-Harel N, Goonewardena VD, Kurotani R, Berdy SE, Swan CH, Rubenstein JL, Robert B, Mellon PL, Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families. J Biol Chem. 2005 May 13;280(19):19156-65
1*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:155096 Han J, Mayo J, Xu X, Li J, Bringas P Jr, Maas RL, Rubenstein JL, Chai Y, Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice. Development. 2009 Dec;136(24):4225-33
1	J:165723 He F, Xiong W, Wang Y, Matsui M, Yu X, Chai Y, Klingensmith J, Chen Y, Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. Dev Biol. 2010 Nov 1;347(1):109-21
1	J:144627 He F, Xiong W, Yu X, Espinoza-Lewis R, Liu C, Gu S, Nishita M, Suzuki K, Yamada G, Minami Y, Chen Y, Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development. Development. 2008 Dec;135(23):3871-9
1*	J:9723 Hill RE, Jones PF, Rees AR, Sime CM, Justice MJ, Copeland NG, Jenkins NA, Graham E, Davidson DR, A new family of mouse homeo box-containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7.1. Genes Dev. 1989 Jan;3(1):26-37
1*	J:139635 Huang X, Goudy SL, Ketova T, Litingtung Y, Chiang C, Gli3-deficient mice exhibit cleft palate associated with abnormal tongue development. Dev Dyn. 2008 Sep 24;237(10):3079-3087
1	J:191714 Jia S, Zhou J, Gao Y, Baek JA, Martin JF, Lan Y, Jiang R, Roles of Bmp4 during tooth morphogenesis and sequential tooth formation. Development. 2013 Jan 15;140(2):423-32
1	J:137800 Jin JZ, Li Q, Higashi Y, Darling DS, Ding J, Analysis of Zfhx1a mutant mice reveals palatal shelf contact-independent medial edge epithelial differentiation during palate fusion. Cell Tissue Res. 2008 Jul;333(1):29-38
1	J:51084 Keranen SV, Aberg T, Kettunen P, Thesleff I, Jernvall J, Association of developmental regulatory genes with the development of different molar tooth shapes in two species of rodents. Dev Genes Evol. 1998 Nov;208(9):477-86
1	J:56749 Keranen SV, Kettunen P, Aberg T, Thesleff I, Jernvall J, Gene expression patterns associated with suppression of odontogenesis in mouse and vole diastema regions. Dev Genes Evol. 1999 Aug;209(8):495-506
1	J:127453 Kettunen P, Spencer-Dene B, Furmanek T, Kvinnsland IH, Dickson C, Thesleff I, Luukko K, Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning. Mech Dev. 2007 Nov-Dec;124(11-12):868-83
1	J:336410 Koo HY, Kim MA, Min H, Hwang JY, Prajapati-DiNubila M, Kim KS, Matzuk MM, Park JW, Doetzlhofer A, Kim UK, Bok J, Follistatin regulates the specification of the apical cochlea responsible for low-frequency hearing in mammals. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2213099120
1	J:147277 Lan Y, Jiang R, Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth. Development. 2009 Apr;136(8):1387-96
1	J:240835 Li CY, Hu J, Lu H, Lan J, Du W, Galicia N, Klein OD, alphaE-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development. Nat Commun. 2016 Jul 13;7:12133
1	J:245974 Li J, Cui Y, Xu J, Wang Q, Yang X, Li Y, Zhang X, Qiu M, Zhang Z, Zhang Z, Suppressor of Fused restraint of Hedgehog activity level is critical for osteogenic proliferation and differentiation during calvarial bone development. J Biol Chem. 2017 Sep 22;292(38):15814-15825
1	J:171428 Li J, Huang X, Xu X, Mayo J, Bringas P Jr, Jiang R, Wang S, Chai Y, SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis. Development. 2011 May;138(10):1977-89
1	J:168033 Li L, Lin M, Wang Y, Cserjesi P, Chen Z, Chen Y, BmprIa is required in mesenchymal tissue and has limited redundant function with BmprIb in tooth and palate development. Dev Biol. 2011 Jan 15;349(2):451-61
1	J:204229 Li L, Wang Y, Lin M, Yuan G, Yang G, Zheng Y, Chen Y, Augmented BMPRIA-mediated BMP signaling in cranial neural crest lineage leads to cleft palate formation and delayed tooth differentiation. PLoS One. 2013;8(6):e66107
1	J:130228 Liu F, Chu EY, Watt B, Zhang Y, Gallant NM, Andl T, Yang SH, Lu MM, Piccolo S, Schmidt-Ullrich R, Taketo MM, Morrisey EE, Atit R, Dlugosz AA, Millar SE, Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol. 2008 Jan 1;313(1):210-24
1	J:222257 Liu Y, Wang M, Zhao W, Yuan X, Yang X, Li Y, Qiu M, Zhu XJ, Zhang Z, Gpr177-mediated Wnt Signaling Is Required for Secondary Palate Development. J Dent Res. 2015 Jul;94(7):961-7
1*	J:1380 MacKenzie A, Ferguson MW, Sharpe PT, Expression patterns of the homeobox gene, Hox-8, in the mouse embryo suggest a role in specifying tooth initiation and shape. Development. 1992 Jun;115(2):403-20
1*	J:31832 MacKenzie A, Ferguson MW, Sharpe PT, Hox-7 expression during murine craniofacial development. Development. 1991 Oct;113(2):601-11
1*	J:20090 Mackenzie A, Leeming GL, Jowett AK, Ferguson MW, Sharpe PT, The homeobox gene Hox 7.1 has specific regional and temporal expression patterns during early murine craniofacial embryogenesis, especially tooth development in vivo and in vitro. Development. 1991 Feb;111(2):269-85
1	J:170543 Matsushima D, Heavner W, Pevny LH, Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6. Development. 2011 Feb;138(3):443-54
1*	J:11525 Monaghan AP, Davidson DR, Sime C, Graham E, Baldock R, Bhattacharya SS, Hill RE, The Msh-like homeobox genes define domains in the developing vertebrate eye. Development. 1991 Aug;112(4):1053-61
1	J:161645 Moretti F, Marinari B, Lo Iacono N, Botti E, Giunta A, Spallone G, Garaffo G, Vernersson-Lindahl E, Merlo G, Mills AA, Ballaro C, Alema S, Chimenti S, Guerrini L, Costanzo A, A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias. J Clin Invest. 2010 May 3;120(5):1570-7
1*	J:121243 Murray SA, Oram KF, Gridley T, Multiple functions of Snail family genes during palate development in mice. Development. 2007 May;134(9):1789-97
1	J:160264 Nakatomi M, Wang XP, Key D, Lund JJ, Turbe-Doan A, Kist R, Aw A, Chen Y, Maas RL, Peters H, Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis. Dev Biol. 2010 Apr 15;340(2):438-49
1*	J:61158 Ngo-Muller V, Muneoka K, Influence of FGF4 on digit morphogenesis during limb development in the mouse. Dev Biol. 2000 Mar 15;219(2):224-36
1*	J:110559 Ogawa T, Kapadia H, Feng JQ, Raghow R, Peters H, D'Souza RN, Functional consequences of interactions between Pax9 and Msx1 genes in normal and abnormal tooth development. J Biol Chem. 2006 Jul 7;281(27):18363-9
1	J:118794 Oka K, Oka S, Sasaki T, Ito Y, Bringas P Jr, Nonaka K, Chai Y, The role of TGF-beta signaling in regulating chondrogenesis and osteogenesis during mandibular development. Dev Biol. 2007 Mar 1;303(1):391-404
1	J:337005 Ozekin YH, O'Rourke R, Bates EA, Single cell sequencing of the mouse anterior palate reveals mesenchymal heterogeneity. Dev Dyn. 2023 Jun;252(6):713-727
1*	J:341657 Park J, Nakatomi M, Sasaguri M, Habu M, Takahashi O, Yoshiga D, Matsuyama K, Kataoka S, Toyono T, Seta Y, Peters H, Tominaga K, Msx1 Heterozygosity in Mice Enhances Susceptibility to Phenytoin-Induced Hypoxic Stress Causing Cleft Palate. Cleft Palate Craniofac J. 2021 Jun;58(6):697-706
1	J:153100 Pauws E, Hoshino A, Bentley L, Prajapati S, Keller C, Hammond P, Martinez-Barbera JP, Moore GE, Stanier P, Tbx22null mice have a submucous cleft palate due to reduced palatal bone formation and also display ankyloglossia and choanal atresia phenotypes. Hum Mol Genet. 2009 Nov 1;18(21):4171-9
1	J:49857 Peters H, Neubuser A, Kratochwil K, Balling R, Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities. Genes Dev. 1998 Sep 1;12(17):2735-47
1*	J:35807 Phippard DJ, Weber-Hall SJ, Sharpe PT, Naylor MS, Jayatalake H, Maas R, Woo I, Roberts-Clark D, Francis-West PH, Liu YH, Maxson R, Hill RE, Dale TC, Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development. Development. 1996 Sep;122(9):2729-37
1	J:24332 Reginelli AD, Wang YQ, Sassoon D, Muneoka K, Digit tip regeneration correlates with regions of Msx1 (Hox 7) expression in fetal and newborn mice. Development. 1995 Apr;121(4):1065-76
1*	J:85739 Rice R, Rice DP, Olsen BR, Thesleff I, Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4. Dev Biol. 2003 Oct 1;262(1):75-87
1	J:162170 Roybal PG, Wu NL, Sun J, Ting MC, Schafer CA, Maxson RE, Inactivation of Msx1 and Msx2 in neural crest reveals an unexpected role in suppressing heterotopic bone formation in the head. Dev Biol. 2010 Jul 1;343(1-2):28-39
1	J:332920 Shibuya S, Nakatomi M, Kometani-Gunjigake K, Nakao-Kuroishi K, Matsuyama K, Kataoka S, Toyono T, Seta Y, Kawamoto T, Msx1 is essential for proper rostral tip formation of the mouse mandible. Biochem Biophys Res Commun. 2023 Jan 29;642:75-82
1	J:198279 Song Z, Liu C, Iwata J, Gu S, Suzuki A, Sun C, He W, Shu R, Li L, Chai Y, Chen Y, Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development. J Biol Chem. 2013 Apr 12;288(15):10440-50
1*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:48144 Treier M, Gleiberman AS, O'Connell SM, Szeto DP, McMahon JA, McMahon AP, Rosenfeld MG, Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev. 1998 Jun 1;12(11):1691-704
1*	J:48939 Tucker AS, Al Khamis A, Sharpe PT, Interactions between Bmp-4 and Msx-1 act to restrict gene expression to odontogenic mesenchyme. Dev Dyn. 1998 Aug;212(4):533-9
1*	J:3324 Wang Y, Benezra R, Sassoon DA, Id expression during mouse development: a role in morphogenesis. Dev Dyn. 1992 Jul;194(3):222-30
1	J:306208 Wu J, Tian Y, Han L, Liu C, Sun T, Li L, Yu Y, Lamichhane B, D'Souza RN, Millar SE, Krumlauf R, Ornitz DM, Feng JQ, Klein O, Zhao H, Zhang F, Linhardt RJ, Wang X, FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling. BMC Biol. 2020 Jul 14;18(1):87
1	J:217590 Yuan G, Yang G, Zheng Y, Zhu X, Chen Z, Zhang Z, Chen Y, The non-canonical BMP and Wnt/beta-catenin signaling pathways orchestrate early tooth development. Development. 2015 Jan 1;142(1):128-39
1*	J:78220 Zhang Z, Song Y, Zhao X, Zhang X, Fermin C, Chen Y, Rescue of cleft palate in Msx1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis. Development. 2002 Sep;129(17):4135-46
1*	J:83306 Zhang Z, Zhang X, Avniel WA, Song Y, Jones SM, Jones TA, Fermin C, Chen Y, Malleal processus brevis is dispensable for normal hearing in mice. Dev Dyn. 2003 May;227(1):69-77
1	J:173121 Zhou J, Gao Y, Zhang Z, Zhang Y, Maltby KM, Liu Z, Lan Y, Jiang R, Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field. Dev Biol. 2011 May 15;353(2):344-53
1	J:154920 Zirzow S, Ludtke TH, Brons JF, Petry M, Christoffels VM, Kispert A, Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse. Dev Biol. 2009 Dec 15;336(2):145-55